mu/mu4e are known to work on a wide variety of Unix- and Unix-like systems, including many Linux distributions, OS X and FreeBSD, and even on MS-Windows (with Cygwin). Emacs 24 or higher is required, as well as Xapian12 and GMime13.
mu has optional support for both versions 2.2 and 3.0 of the Guile (Scheme) programming language. There are also some GUI-toys, which require GTK+ 3.x and Webkit.
If you intend to compile mu yourself, you need to have the typical
development tools, such as C and C++ compilers (both
clang should work), GNU Autotools and
the development packages for GMime 3.x, GLib and Xapian. Optionally,
you also need the development packages for GTK+, Webkit and Guile.