An (almost) minimal configuration for mu4e might look like this — as you see, most of it is commented-out.
;; example configuration for mu4e ;; make sure mu4e is in your load-path (require 'mu4e) ;; use mu4e for e-mail in emacs (setq mail-user-agent 'mu4e-user-agent) ;; these must start with a "/", and must exist ;; (i.e.. /home/user/Maildir/sent must exist) ;; you use e.g. 'mu mkdir' to make the Maildirs if they don't ;; already exist ;; below are the defaults; if they do not exist yet, mu4e offers to ;; create them. they can also functions; see their docstrings. ;; (setq mu4e-sent-folder "/sent") ;; (setq mu4e-drafts-folder "/drafts") ;; (setq mu4e-trash-folder "/trash") ;; smtp mail setting; these are the same that `gnus' uses. (setq message-send-mail-function 'smtpmail-send-it smtpmail-default-smtp-server "smtp.example.com" smtpmail-smtp-server "smtp.example.com" smtpmail-local-domain "example.com")